Mechanical alignment is part of cleaning performance.
A wash process cannot compensate for a nozzle that repeatedly misses the bottle opening or for a bottle that is unstable during inversion. Neck diameter, offset, shoulder shape, pitch, guide position and holder design all influence whether the intended surfaces receive the wash and whether liquid drains rather than carrying soil into the next stage.
Direct answer: test the smallest neck opening, least stable bottle and most difficult internal geometry at the intended pitch and speed; confirm nozzle entry or spray aim, bottle retention, internal and external coverage, drainage and repeatability after a format change.